Tolbutamide is a first-generation potassium channel blocker, sulfonylurea oral hypoglycemic drug originally sold under the brand name Orinase. This drug may be used in the management of type 2 diabetes if diet alone is not effective. Tolbutamide stimulates the secretion of insulin by the pancreas. Since the pancreas must synthesize insulin for this drug to work, it is not effective in the management of type 1 diabetes. It is not routinely used due to a higher incidence of adverse effects compared to newer, second-generation sulfonylureas, such as glyburide. It generally has a short duration of action due to its rapid metabolism, so is safe for use in elderly diabetic patients.

CAS：64-77-7
中文别名：1-正丁基-3-(4-甲基磺酰)脲;甲磺丁脲;1-丁基-3-(4-甲苯磺酰基)脲;
英文别名：[3H]-Tolbutamide;1-(p-toluenesulfonyl)-3-n-butyl-urea;Tolbutamide;Diabetol;Orinase;Dolipol;Dirastan;[14C]-Tolbutamide;Diaben;Artosin;1-butyl-3-(4-methylphenyl)sulfonylurea;Rastinon;Glyconon;Benzenesulfonamide, N-[(butylamino)carbonyl]-4-methyl-;N-(butylcarbamoyl)-4-methylbenzenesulfonamide;Butamide;
分子式：C12H18N2O3S
分子量：270.348
精确质量：270.104
Psa：83.65
Logp：3.6456

MDL号：MFCD00027169

外观与性状：白色结晶粉末
密度：1.184 g/cm3
熔点：128-130°C
稳定性：Stable. Combustible.
储存条件：库房低温通风干燥,与食品原料分开存放

RTECS号：YS4550000
安全说明：S26-S36/37/39
危险类别码：R20/21/22
WGK Germany：2
海关编码：2935009090

生产方法
由异氰酸丁酯与对甲苯磺酰胺缩合制得，或由正丁胺盐酸盐与甲苯磺酰脲缩合而成。 降血糖药，适用于稳定型的轻、中度的成年糖尿病患者。
用途
降血糖药，适用于稳定型的轻、中度的成年糖尿病患者。