Clofibrate (tradename Atromid-S) is an organic compound. It is marketed as a fibrate. It is a lipid-lowering agent used for controlling the high cholesterol and triacylglyceride level in the blood. It increases lipoprotein lipase activity to promote the conversion of VLDL to LDL, and hence reduce the level of VLDL. It can increase the level of HDL as well.

CAS：637-07-0
中文别名：氯贝丁酯;氯苯丁酯;对氯苯氧异丁酸乙酯,氯贝丁酯;α-对氯苯氧基-α-甲基丙酸乙酯;对氯苯氧异丁酸乙酯;
英文别名：Arterioflexin;Antilipid;Angiokapsul;2-(p-chlorophenoxy)isobutyric acid ethyl ester;clofibric acid;ethyl p-chlorophenoxy-isobutyrate;Atromid-S;Atromid;Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, ethyl ester;Anparton;Clofibratum;ethyl 2-(4-chlorophenoxy)-2-methylpropanoate;Clofibrato;
分子式：C12H15ClO3
分子量：242.699
精确质量：242.071
Psa：35.53
Logp：3.0605

UNII：HPN91K7FU3

外观与性状：透明无色油状
密度：1.14g/mLat 25°C(lit.)
沸点：154 °C
闪点：113°C
折射率：n20/D 1.503
稳定性：Sensitive to oxidation and light; easily hydrolyzed.
储存条件：通风低温干燥

RTECS号：UE9480000
安全说明：S26-S36/37/39-S61-S45-S36/37
危险类别码：R22; R40
WGK Germany：3
危险品运输编码：UN 3082 9/PG 3
海关编码：2918990090
危险品标志：Xn
危险性描述：H302; H315; H318; H335
危险标志：GHS05, GHS07
危险性防范说明：P261; P280; P305 + P351 + P338
信号词：Danger

生产方法
按照采用的原料划分,该品合格路线主要有两条,一是以对氨基苯酚为原料经重氮化;置换制得对氯苯酚,再经缩合;水解,酸化生成对氯苯氧异丁酸,最后酯化得安妥明。这条路线步骤较长,所用原料对氨基酚不稳定,但比较成熟。二是以苯酚为原料,经缩合生成苯氧异丁酸,再于乙醇中通氯,进行氯化及酯化反应生成安妥明。 用于脑血栓、脑动脉硬化、脑外伤后遗症、内耳眩晕症、冠状动脉硬化及由末梢循环不良引起的疾病。
用途
用于脑血栓、脑动脉硬化、脑外伤后遗症、内耳眩晕症、冠状动脉硬化及由末梢循环不良引起的疾病。