5,5-Diphenyl Hydantoin Sodium salt reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na+, K+, and Ca2+ channels.

CAS：630-93-3
中文别名：大伦丁;5,5-二苯基乙内酰脲钠盐;5,5-二苯乙内酰脲钠;地伦丁;5,5-二苯基-2,4-咪唑烷二酮钠盐;二苯乙内酰脲钠;
英文别名：epinat;tacosal;di-len;eptoin;5,5-diphenylhydantoin sodium;alepsin;5,5-diphenylimidazolidine-2,4-dione sodium salt;solantyl;enkefal;ditoin;dihydan;phenytoin sodium salt;epelin;dilantin sodium;5,5-diphenyl-hydantoine;
分子式：C15H11N2NaO2
分子量：274.25
精确质量：274.072
Psa：49.41
Logp：2.213

MDL号：MFCD00069674

外观与性状：白色粉末
沸点：428.2ºC at 760 mmHg
熔点：290-299ºC
闪点：212.8ºC
稳定性：Sensitive to light phenytoin a slight yellowing of the solution will not affect its potency. After being refrigerated, solution may form a precipitate which usually dissolves after being warmed to room temperature; however, do not use if the solution is no
储存条件：Storage location should be close to laboratory where it is to be used, so that only small amounts need to be transported. Carcinogens should be kept in only one section of storage area, explosion-proof refrigerator or freezer as required. The area should b

RTECS号：MU1400000
安全说明：S22-S36/37/39-S45
危险类别码：R22; R43; R62; R63
WGK Germany：3
海关编码：2933990090
危险品运输编码：UN 2811 6.1/PG 3
危险类别：6.1(b)
包装等级：III
危险品标志：Xn
危险性防范说明：P280
危险标志：GHS07, GHS08
危险性描述：H302; H317; H361
信号词：Warning

生产方法
苯甲醛经缩合、氧化得到联苯甲酰，然后与尿素重排、环合得到苯妥英钠。将水、尿素及联苯甲酰依次加入反应锅，搅拌加热至98℃，加入30%氢氧化钠，回流1.5h。加水及适量少性炭脱色，冷至26-28℃，过滤，滤液用5%左右盐酸酸化至pH=5-6，温度45-55℃，过滤，用水洗涤，得苯妥英。将苯妥英投入碱液中加热溶解，用氢氧化钠溶液调节pH至11-11.5，加活万籁 炭于75-80℃脱色半小时。压滤，冷至37-38℃，加入晶种放置结晶。冷至25℃过滤，结晶用蒸馏水洗涤，甩干，粉碎，于80℃左右干燥，得苯妥英钠。 抗癫痫药及抗心律失常药。对癫痫大发作疗效好，对精神运动性发作和局限性发作次之，对小发作不但无效，甚至能诱发。
用途
抗癫痫药及抗心律失常药。对癫痫大发作疗效好，对精神运动性发作和局限性发作次之，对小发作不但无效，甚至能诱发。