Amrinone (INN) or inamrinone (USAN, changed in 2000 to prevent confusion with amiodarone), trade name Inocor, is a pyridine phosphodiesterase 3 inhibitor. It is a drug that may improve the prognosis in patients with congestive heart failure. Amrinone has been shown to increase the contractions initiated in the heart by high gain calcium induced calcium release (CICR). The positive inotropic effect of amrinone is mediated by the selective enhancement of high gain CICR which contributes to the contraction of myocytes by phosphorylation through cAMP dependent protein kinase A (PKA) and Ca2+ calmodulin kinase pathways.

CAS：60719-84-8
中文别名：5-氨基-[3,4\'双吡啶]-6(1H)-酮;
英文别名：Amrinon;Cordemcura;inamrinone;Inocor;Amrinone;Amrinona;Wincoram;Amcoral;Amrinonum;
分子式：C10H9N3O
分子量：187.198
精确质量：187.075
Psa：71.77
Logp：1.6003

MDL号：MFCD00083228

外观与性状：结晶固体
密度：1.277 g/cm3
沸点：451.5ºC at 760 mmHg
熔点：294-297ºC
闪点：226.9ºC
折射率：1.625
储存条件：库房通风低温干燥

RTECS号：DW2500000
安全说明：S28-S45
WGK Germany：3
危险类别码：R25
危险品运输编码：UN 2811
海关编码：29333999
危险类别：6.1(b)
包装等级：III
危险品标志：T

用途
强心药、具有增强心肌收缩力和直接扩张血管作用