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化合物简介

Raphanin is the main sulfur component found in radish seeds of Raphanus sativus and is also found in broccoli and red cabbage. It was first described by G. Ivanovics and S. Horvath in 1947. Raphanin inhibits activity of viruses, some fungi and various bacteria including Staphylococus, Streptococus, Pneumococcus and Escherichia coli (see table). The effect is stronger against Gram-positive than Gram-negative bacteria and against DNA than RNA viruses; it is suppressed by serum and by sulfur compounds such as hydrogen sulfide, mercaptoacetic acid, cystine and glutathione. The antibacterial, antifungal and antiviral effects from consuming radishes were recognized in traditional Chinese medicine. Given that Raphanin can be chiefly responsible for keeping the production of thyroxine and calcitonin in normal balance, in Russia, radishes have long been used for treating both types of thyroid problems. However, in the abstract to his 1947 paper, Ivanovics noted that because raphanin is highly toxic, it did not \"hold the promise of a useful therapeutic agent\".; Minimum inhibitory concentration of raphanin Bacteria MIC (mg/mL) Staphylococus 0.04 Shigella dysenteriae 0.125 Salmonella typhi 0.125 Escherichia coli 0.2

基本信息

CAS:592-95-0
中文别名:(E)-4-异硫氰酸基-1-(甲基亚磺酰基)-1-丁烯;
英文别名:SULFORAPHENE,L;L-SULPHORAPHENE;sativin;4-isothiocyanato-1-(methylsulfinyl)-1-buten;L-SULFORAPHENE;S-SULFORAPHENE;RAPHANIN;4-methylsulfinyl-3-butenyl isothiocyanate;SULFORAPHANE,DL-(SH);4-Methylsulfinyl-3-butenyl-isothiocyanat (Sulphoraphen);
分子式:C6H9NOS2
分子量:175.272
精确质量:175.013
Psa:80.73
Logp:2.2372

编号系统

MDL号:MFCD00189462

物化性质

外观与性状:略淡黄色液体
密度:1.16 g/cm3
沸点:362.2ºC at 760 mmHg
闪点:172.8ºC
折射率:1.566

安全信息

生产方法及用途

合成路线

  • 参考文献

    Journal of Agricultural and Food Chemistry, , vol. 56, # 3 p. 875 - 883

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13C NMR : Predict


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