Ubenimex (INN), also known more commonly as bestatin, is a competitive, reversible protease inhibitor. It is an inhibitor of arginyl aminopeptidase (aminopeptidase B), leukotriene A4 hydrolase (a zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities), alanyl aminopeptidase (aminopeptidase M/N), leucyl/cystinyl aminopeptidase (oxytocinase/vasopressinase), and membrane dipeptidase (leukotriene D4 hydrolase). It is being studied for use in the treatment of acute myelocytic leukemia. It is derived from Streptomyces olivoreticuli. Ubenimex has been found to inhibit the enzymatic degradation of oxytocin, vasopressin, enkephalins, and various other peptides and compounds.

CAS：58970-76-6
中文别名：[S-(R*,S*)]-N-(3-氨基-2-羟基-1-氧代-4-苯丁基)-L-亮氨酸;贝他定;N-[(2S,3R)-3-氨基-2-羟基-4-苯丁酰]-L-亮氨酸;N-[(2S,3R)-3-氨基-2-羟基-4-苯基丁酰基]-L-亮氨酸;([2S,3R]-3-氨基-2-羟基-4-苯基丁酰基)-L-亮氨酸;
英文别名：nk421;BENIMEX;BESTATIN;Bestatin,UbeniMex;
分子式：C16H24N2O4
分子量：308.373
精确质量：308.174
Psa：112.65
Logp：1.624

UNII：I0J33N5627

外观与性状：白色结晶粉末
密度：1.197 g/cm3
沸点：604.7ºC at 760 mmHg
熔点：245°C (dec.)(lit.)
闪点：319.5ºC
折射率：1.557
稳定性：Stable at normal temperatures and pressures.
储存条件：通风低温干燥,与库房食品原料分开存放

RTECS号：OH2915000
安全说明：S22-S24/25
WGK Germany：3

用途
急、慢性细胞性白血病等病的辅助治疗