Prochlorperazine (Compazine, Stemzine, Buccastem, Stemetil, Phenotil) is a dopamine (D2) receptor antagonist that belongs to the phenothiazine class of antipsychotic agents that are used for the antiemetic treatment of nausea and vertigo. It is also a highly potent typical antipsychotic, 10–20 times more potent than chlorpromazine. It is also used to treat migraine headaches. Intravenous administration can be used to treat status migrainosus.

CAS：58-38-8
中文别名：过二苯嗪;6-氨基-2-(氟甲基)-3-(2-甲基苯基)-4-(3H)-1,3-二氮杂萘酮;诺安命;普鲁氯嗪;氯吡嗪;普洛陪拉幸;
英文别名：proclorperazine;RP-6140;Temetid;Nipodal;10H-Phenothiazine, 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-;6140 RP;skf4657;Capazine;Emelent;Prochlorperazine;Eskatrol;Antinaus;2-Chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine;Buccastem;Bukatel;Chlormeprazine;Chloropernazine;Compazine;Ametil;Emedrotec;Dhaperazine;Compro;Emetiral;Mitil;Lotamin;Eminorm;Mormal;Daolin;Novamin;Proazine;Procalm;Prochlorperazin;Prochlorpérazine;Prochlorperazinum;Prochlozine;Novomit;Nautisol;Proclorperazina;Roumin;Scripto-metic;Promtil;Seratil;Stemetil;Steremal;Vergon;Promat;Promin;Volimin;Vestil;
分子式：C20H24ClN3S
分子量：373.943
精确质量：373.138
Psa：35.02
Logp：4.521

UNII：YHP6YLT61T

外观与性状：透明淡黄色粘性液体
密度：1.217g/cm3
沸点：524.8ºC at 760mmHg
熔点：228 °C
闪点：271.2ºC
稳定性：Stable at normal temperatures and pressures.
储存条件：Protect from light. Keep in a tightly closed container in a cool, dry location.

安全说明：S26-S36/37/39-S45-S38-S28A-S36-S16
WGK Germany：3
海关编码：29159020
危险品运输编码：UN 3261 8/PG 2
危险类别：8
包装等级：II

生产方法
N-(2-羟乙基)哌嗪与1,3-溴氯丙烷缩合得到1-(3-氯丙基)-4-(2-羟乙基)哌嗪。然后,将其与2-氯吩噻嗪缩合,制得奋乃静粗品。用乙酸乙酯重结晶,即得成品。 用于治疗急慢性精神分裂症
用途
用于治疗急慢性精神分裂症