1-(-1-Naphthyl)piperazine (1-NP) is a drug which is a phenylpiperazine derivative. It acts as a non-selective, mixed serotonergic agent, exerting partial agonism at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F receptors, while antagonizing the 5-HT2A, 5-HT2B, and 5-HT2C receptors. It has also been shown to possess high affinity for the 5-HT3, 5-HT5A, 5-HT6, and 5-HT7 receptors, and may bind to 5-HT4 and the SERT as well. In animals it produces effects including hyperphagia, hyperactivity, and anxiolysis, of which are all likely mediated predominantly or fully by blockade of the 5-HT2C receptor.

CAS：57536-86-4
中文别名：1-(1-萘)哌嗪盐酸盐;
英文别名：NPPI;1-NAPHTHALENE-1-YL-PIPERAZINE HCL;naphthylpiperazine;1-NAPHTHALEN-1-YL-PIPERAZINE HYDROCHLORIDE;
分子式：C14H17ClN2
分子量：248.751
精确质量：248.108
Psa：15.27
Logp：3.4452

外观与性状：白色至黄褐色的粉末
密度：1.106 g/cm3
沸点：391.9ºC at 760 mmHg
熔点：280°C (dec.)
闪点：188.9ºC
折射率：1.622

安全说明：S26-S36/37/39
危险类别码：R36/37/38
WGK Germany：3