Chlorotrianisene (INN, USAN, BAN; brand names Tace, Estregur, Anisene, Clorotrisin, Merbentyl, Triagen, many others; also known as CTA; tri-p-anisylchloroethylene, TACE, or tris(p-methoxyphenyl)chloroethylene) is a synthetic, non-steroidal estrogen of the triphenylethylene group that was formerly used for the treatment of menopausal symptoms, estrogen deficiency, and prostate cancer before being discontinued. It was approved in the United States as TACE in 1952, and was introduced throughout Europe subsequently. CTA was the first estrogenic compound of the triphenylethylene series to be introduced.

CAS：569-57-3
中文别名：泰舒;
英文别名：Chlorotrianisine;Chlorestrolo;TACE;Merbentul;Chlorotrianizen;Tris-(4-methoxy-phenyl)-vinylchlorid;1-[1-chloro-2,2-bis(4-methoxyphenyl)ethenyl]-4-methoxybenzene;Chlortrianisestrol;chloro-tris-(4-methoxy-phenyl)-ethene;Chlortrianisen;Benzene, 1,1‘,1‘‘-(1-chloro-1-ethenyl-2-ylidene)tris[4-methoxy-;Chlor-tris-(4-methoxy-phenyl)-aethen;Chlortrianizen;Chloortrianisestrol;1-chloro-1,2,2-tris(p-methoxyphenyl)ethene;1,1\',1\'\'-(1-chloro-1-ethenyl-2-ylidene)tris[4-methoxy-benzene];2-Chlor-1,1,2-tris-(4-methoxy-phenyl)-aethylen;Chlorotrianisene;
分子式：C23H21ClO3
分子量：380.864
精确质量：380.118
Psa：27.69
Logp：5.8678

UNII：6V5034L121

密度：1.168g/cm3
沸点：514.2ºC at 760mmHg
熔点：114-116ºC
闪点：164.1ºC
折射率：1.591

RTECS号：KV0600000
WGK Germany：3

生产方法
有多种合成路线,由对甲氧基苯乙酮经溴化、成盐、缩合、氯化而得。总收率14.5%;也可由茴香酸出发制备,总收率44.4%,但茴香酸原料价格较贵。以茴香醚为原料,经下列步骤制取泰舒,总收率为21.6%。 雌激素类药,主要用于治疗前列腺肿大和妇女更年期综合症。
用途
雌激素类药,主要用于治疗前列腺肿大和妇女更年期综合症。