Tetrahydrodeoxycorticosterone (abbreviated as THDOC; 3α,21-dihydroxy-5α-pregnan-20-one), also referred to as allotetrahydrocorticosterone, is an endogenous neurosteroid. It is synthesized from the adrenal hormone deoxycorticosterone by the action of two enzymes, 5α-reductase type I and 3α-hydroxysteroid dehydrogenase. THDOC is a potent positive allosteric modulator of the GABAA receptor, and has sedative, anxiolytic and anticonvulsant effects. Changes in the normal levels of this steroid particularly during pregnancy and menstruation may be involved in some types of epilepsy (catamenial epilepsy) and premenstrual syndrome, as well as stress, anxiety and depression.

CAS：567-03-3
中文别名：
英文别名：TETRAHYDRODEOXYCORTICOSTERONE;
分子式：C21H34O3
分子量：334.493
精确质量：334.251
Psa：57.53
Logp：3.5676

EINECS号：209-301-3

密度：1.115g/cm3
沸点：470.3ºC at 760mmHg
闪点：252.3ºC
折射率：1.54