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化合物简介

Cantharidin is an odorless, colorless terpene secreted by many species of blister beetles, including broadly in genus Epicauta, and in species Lytta vesicatoria (Spanish fly). False blister beetles, cardinal beetles, and soldier beetles also produce cantharidin. Poisoning from the substance is a significant veterinary concern, especially in horses from the Epicauta species, but it can also be poisonous to humans if taken internally (where the origin is most often experimental self-exposure). Externally, cantharidin is a potent vesicant (blistering agent), exposure to which can cause severe chemical burns. Properly dosed and applied, the same properties have been used for effective topical medications for some conditions, such as treating patients with Molluscum contagiosum infection of the skin.

基本信息

CAS:56-25-7
中文别名:六氢-3a,7a-二甲基-4,7-环氧异苯并呋喃-1,3-二酮;班蝥素;
英文别名:2endo,3endo-dimethyl-7-oxa-norbornane-2exo,3exo-dicarboxylic acid-anhydride;3a,7a-dimethyl-(3at,7at)-hexahydro-4r,7c-epioxido-isobenzofuran-1,3-dione;cantharides;2,3-dimethyl anhydride;Canthari;Antharidin;Kantaridin;Cantharone;7aalpha)-t;Cantharidin;4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-3a,7a-dimethyl-, (3aα,4β,7β,7aα)-;Kantharidin;7aalpha)-bet;2,3-dimethyl-7-oxa-bicyclo[2.2.1]heptane-2exo,3exo-dicarboxylic acid anhydride;2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid anhydride;Camptothecine;
分子式:C10H12O4
分子量:196.2
精确质量:196.074
Psa:52.6
Logp:0.6436

编号系统

UNII:IGL471WQ8P

物化性质

外观与性状:白色晶体
密度:1.362g/cm3
沸点:326.9ºC at 760mmHg
熔点:215-217°C(lit.)
折射率:1.547
稳定性:Stable at normal temperatures and pressures.
储存条件:库房通风低温干燥,与食品原料分开储运

安全信息

RTECS号:RN8575000
安全说明:S53-S45
WGK Germany:3
危险类别码:R28; R36/37/38
危险品运输编码:UN 2811 6.1/PG 1
危险类别:6.1(a)
包装等级:I
危险品标志:T+
危险性描述:H300; H315; H319; H335
危险标志:GHS06
信号词:Danger
危险性防范说明:P305 + P351 + P338

生产方法及用途

生产方法
1.斑蝥素是从鞘翅类地胆科斑蝥属昆虫斑蝥中提取的一种单萜烯类物质,成虫中含量为1%左右。 首先将斑蝥粉碎成粉状。按斑蝥虫粗粉∶浓盐酸∶丙酮=1∶0.025∶5.5的比例投料。取干燥粗粉加入浓盐酸,然后加入3倍量的丙酮,浸泡提取48h,然后用双层纱布过滤,收集滤液,残渣再用 1.斑蝥素可以抑制癌细胞的蛋白质和核酸的合成,从而控制其大量增殖。对治疗原发性肝癌有一定疗效,常与其他抗肿瘤药配合使用。另外,对乳腺癌、食道癌、白细胞下降、肺癌以及慢性肝炎等病症也有一定疗效。
用途
1.斑蝥素可以抑制癌细胞的蛋白质和核酸的合成,从而控制其大量增殖。对治疗原发性肝癌有一定疗效,常与其他抗肿瘤药配合使用。另外,对乳腺癌、食道癌、白细胞下降、肺癌以及慢性肝炎等病症也有一定疗效。

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Predict 1H proton NMR


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1H NMR : Predict


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