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  • 硝唑尼特

    [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate

化合物简介

Nitazoxanide is a broad-spectrum antiparasitic and broad-spectrum antiviral drug that is used in medicine for the treatment of various helminthic, protozoal, and viral infections. It is indicated for the treatment of infection by Cryptosporidium parvum and Giardia lamblia in immunocompetent individuals and has been repurposed for the treatment of influenza. Nitazoxanide has also been shown to have in vitro antiparasitic activity and clinical treatment efficacy for infections caused by other protozoa and helminths; emerging evidence suggests that it possesses efficacy in treating a number of viral infections as well.

基本信息

CAS:55981-09-4
中文别名:硝唑克酰胺;邻[N-(5-硝基噻唑-2-基)氨基甲酰]苯酚乙酸酯;
英文别名:[14C]-Nitazoxanide;Cryptaz;Nitazoxanide;Heliton;Colufase;Nitazoxanida;NITAZOXANIDE;Alinia;Nitazoxanidum;Daxon;Nitazoxamide;
分子式:C12H9N3O5S
分子量:307.282
精确质量:307.026
Psa:142.35
Logp:2.8251

编号系统

MDL号:MFCD00416599

物化性质

外观与性状:淡黄色至白色结晶粉末
密度:1.532 g/cm3
熔点:202ºC
储存条件:-20ºC Freezer

安全信息

海关编码:2942000000
危险性防范说明:P261; P305 + P351 + P338
危险性描述:H302; H315; H319; H335
信号词:Warning
危险标志:GHS07

生产方法及用途

合成路线

  • 参考文献

    European Journal of Medicinal Chemistry, , vol. 13, # 6 p. 539 - 543

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图谱

Predict 1H proton NMR


13C NMR : Predict


1H NMR : Predict


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