Methyldopa (L-α-Methyl-3,4-dihydroxyphenylalanine; Aldomet, Aldoril, Dopamet, Dopegyt, etc.) is a centrally acting antihypertensive agent. It is metabolized to alpha-methylnorepinephrine in the brain, and this compound is thought to activate central alpha-2 adrenergic receptors (Gerber, 1990). Being a selective agonist for α2 adrenergic receptors, psychoactive drug is used as a sympatholytic or antihypertensive. Its use is now mostly deprecated following the introduction of alternative safer classes of agents. However, it continues to have a role in otherwise difficult to treat hypertension and gestational hypertension (previously known as pregnancy-induced hypertension (PIH)).

CAS：555-30-6
中文别名：L-甲基多巴;3-(3,4-二羟基苯基)-2-甲基-L-丙氨酸;2-氨基-3-(3,4-二羟基苯基)-2-甲基-丙酸;
英文别名：alpha-methyl-L-dopa;L-Tyrosine, 3-hydroxy-α-methyl-;Methyldopa Sesquihydrate;Methyldopa;α-methyl-L-dopa;
分子式：C10H13NO4
分子量：211.215
精确质量：211.084
Psa：103.78
Logp：1.1426

UNII：M4R0H12F6M

外观与性状：无色或近乎于无色晶体或白色至淡黄色-白色细粉末，在水合物形态时近乎于没味道
密度：1.403g/cm3
沸点：441.6ºC at 760mmHg
熔点：≥300°C
闪点：220.9ºC
折射率：-14 ° (C=1, H2O)
水溶解性：溶于水
可溶性：DMSO(75 mM),稀盐酸
稳定性：Stable under normal temperatures and pressures.
储存条件：Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.

RTECS号：YP2860000
安全说明：S24/25
WGK Germany：3
海关编码：2918199090

生产方法
一、生产方法简述 将香兰醛用硫酸二甲酯甲基化为藜芦醛,再与硝基乙烷缩合得到1-(2-硝基丙烯基)-3',4'-二甲氧基苯,用铁粉还原并经水解后生成3',4'-二甲氧基苯丙酮(见149 左旋甲基多巴是一种B-受体阻滞型心血管药物，对中等程序的原发性和肾性高血压有良好疗效。
用途
左旋甲基多巴是一种B-受体阻滞型心血管药物，对中等程序的原发性和肾性高血压有良好疗效。