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  • L-甲状腺素钠盐五水合物

    levothyroxine sodium anhydrous

化合物简介

One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.

基本信息

CAS:55-03-8
中文别名:左甲状腺素钠;L-甲状腺素钠;L-甲状腺素钠五水合物;
英文别名:(S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionic Acid Sodium Salt Pentahydrate;Levothyroxine sodium;
分子式:C15H20I4NNaO9
分子量:888.928
精确质量:888.721
Psa:141.76
Logp:3.6014

编号系统

UNII:054I36CPMN

物化性质

沸点:576.3ºC at 760 mmHg
熔点:207-210 (dec.)(lit.)ºC
闪点:302.3ºC
储存条件:2-8ºC

安全信息

安全说明:S22-S24/25
危险品运输编码:UN 2811
危险类别:6.1(a)
包装等级:II

生产方法及用途

合成路线

  • 参考文献

    CADILA PHARMACEUTICALS LTD. Patent: WO2009/136249 A1, 2009 ; Location in patent: Page/Page column 5 ;

上游原料

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图谱

Predict 1H proton NMR


13C NMR : Predict


1H NMR : Predict


IR : KBr disc


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