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化合物简介
Epiestriol (INN) (brand names Actriol, Arcagynil, Klimadoral), or epioestriol (BAN), also known as 16β-epiestriol or simply 16-epiestriol as well as 16β-hydroxy-17β-estradiol, is an endogenous, steroidal, weak estrogen, and the 16-epimer of estriol (which is 16α-hydroxy-17β-estradiol). Epiestriol is (or has previously been) used clinically in the treatment of acne. In addition to its estrogenic actions, epiestriol has been found to possess significant anti-inflammatory properties without glycogenic activity or immunosuppressive effects, an interesting finding that is in contrast to conventional anti-inflammatory steroids like hydrocortisone (a glucocorticoid).
基本信息
CAS:547-81-9
中文别名:异雌三醇;雌三醇杂质F;
英文别名:16beta-hydroxyestradiol;16-Epiestratriol;16-epioestriol;EPIESTRIOL,16;Actriol;16b,17b-Estriol;16-EPISTRIOL;Epioestriol;Epiestriol;Estriol (3,16.β.,17.β.);16-EPIESTRIOL;Estra-1,3,5(10)-triene-3,16,17-triol, (16β,17β)-;
分子式:C18H24O3
分子量:288.381
精确质量:288.173
Psa:60.69
Logp:2.58
中文别名:异雌三醇;雌三醇杂质F;
英文别名:16beta-hydroxyestradiol;16-Epiestratriol;16-epioestriol;EPIESTRIOL,16;Actriol;16b,17b-Estriol;16-EPISTRIOL;Epioestriol;Epiestriol;Estriol (3,16.β.,17.β.);16-EPIESTRIOL;Estra-1,3,5(10)-triene-3,16,17-triol, (16β,17β)-;
分子式:C18H24O3
分子量:288.381
精确质量:288.173
Psa:60.69
Logp:2.58
编号系统
UNII:8XZ32LI44K
物化性质
密度:1.255g/cm3
沸点:469ºC at 760 mmHg
熔点:289-291ºC
闪点:220.8ºC
折射率:1.624
储存条件:-20ºC Freezer
沸点:469ºC at 760 mmHg
熔点:289-291ºC
闪点:220.8ºC
折射率:1.624
储存条件:-20ºC Freezer
安全信息
WGK Germany:3
生产方法及用途
合成路线
上游原料
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图谱
13C NMR : Predict

1H NMR : Predict
