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  • 表雌三醇

    16β-hydroxyestradiol

化合物简介

Epiestriol (INN) (brand names Actriol, Arcagynil, Klimadoral), or epioestriol (BAN), also known as 16β-epiestriol or simply 16-epiestriol as well as 16β-hydroxy-17β-estradiol, is an endogenous, steroidal, weak estrogen, and the 16-epimer of estriol (which is 16α-hydroxy-17β-estradiol). Epiestriol is (or has previously been) used clinically in the treatment of acne. In addition to its estrogenic actions, epiestriol has been found to possess significant anti-inflammatory properties without glycogenic activity or immunosuppressive effects, an interesting finding that is in contrast to conventional anti-inflammatory steroids like hydrocortisone (a glucocorticoid).

基本信息

CAS:547-81-9
中文别名:异雌三醇;雌三醇杂质F;
英文别名:16beta-hydroxyestradiol;16-Epiestratriol;16-epioestriol;EPIESTRIOL,16;Actriol;16b,17b-Estriol;16-EPISTRIOL;Epioestriol;Epiestriol;Estriol (3,16.β.,17.β.);16-EPIESTRIOL;Estra-1,3,5(10)-triene-3,16,17-triol, (16β,17β)-;
分子式:C18H24O3
分子量:288.381
精确质量:288.173
Psa:60.69
Logp:2.58

编号系统

UNII:8XZ32LI44K

物化性质

密度:1.255g/cm3
沸点:469ºC at 760 mmHg
熔点:289-291ºC
闪点:220.8ºC
折射率:1.624
储存条件:-20ºC Freezer

安全信息

WGK Germany:3

生产方法及用途

合成路线

上游原料

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图谱

13C NMR : Predict


1H NMR : Predict


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