Pentylenetetrazol, also known as pentylenetetrazole, metrazol, pentetrazol (INN), pentamethylenetetrazol, Corazol, Cardiazol or PTZ, is a drug formerly used as a circulatory and respiratory stimulant. High doses cause convulsions, as discovered by the Hungarian-American neurologist and psychiatrist Ladislas J. Meduna in 1934. It has been used in convulsive therapy, and was found to be effective—primarily for depression—but side-effects such as uncontrolled seizures were difficult to avoid. In 1939 pentylenetetrazol was replaced by electroconvulsive therapy, easier to administer, as the preferred method for inducing seizures in England's mental hospitals. In the US its approval by the FDA was revoked in 1982. It is used in Italy as a cough suppressant.

CAS：54-95-5
中文别名：戊四氮;
英文别名：6,7,8,9-tetrahydro-5H-tetrazolo[1,5-a]azepine;5H-Tetrazolo[1,5-a]azepine, 6,7,8,9-tetrahydro-;Pentylenetetrazole;
分子式：C6H10N4
分子量：138.17
精确质量：138.091
Psa：43.6
Logp：0.3995

MDL号：MFCD00005939

外观与性状：白色结晶粉末
密度：1.73 g/cm3 (20ºC)
沸点：194°C12mm Hg(lit.)
熔点：59-61°C(lit.)
闪点：194°C/12mm
折射率：1.494 (20ºC)
稳定性：Stable. Incompatible with strong oxidizing agents.
储存条件：-20ºC

RTECS号：XF8225000
安全说明：S26-S36/37/39-S45
WGK Germany：3
危险类别码：R25; R36/37/38
海关编码：2933990090
危险品运输编码：UN 2811 6.1/PG 3
危险类别：6.1
包装等级：II
危险品标志：T

生产方法
用环己酮与叠氮酸反应制取 强心剂。生化研究。
用途
强心剂。生化研究。