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化合物简介
Pilocarpine is a drug used to treat dry mouth and glaucoma. It is a parasympathomimetic alkaloid obtained from the leaves of tropical South American shrubs from the genus Pilocarpus. It is a non-selective muscarinic receptor agonist in the parasympathetic nervous system, which acts therapeutically at the muscarinic acetylcholine receptor M3 due to its topical application, e.g., in glaucoma and xerostomia.
基本信息
CAS:54-71-7
中文别名:(3S,4R)-4,5-二氢-3-乙基-4-(1-甲基-1H-咪唑-5-基甲基)-2(3H)-呋喃酮盐酸盐;氨噻唑;(+)-毛果芸香碱盐酸盐;
英文别名:(3S,4R);pilocel;Akarpine;Pilocarpine HCl;Salagen;pilocarpine,2(3H)-furanone,3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)-methyl] monohydrochloride,(3S-cis);2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, monohydrochloride, (3S-cis)-;(3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)-methyl]dihydrofuran-2(3H)one hydrochloride;pilovisc;Sanpilo;Pilocarpine (Hydrochloride);pilocar;ami-pilo;amisturap;pilocarpine HCl;
分子式:C11H17ClN2O2
分子量:244.718
精确质量:244.098
Psa:44.12
Logp:1.9638
中文别名:(3S,4R)-4,5-二氢-3-乙基-4-(1-甲基-1H-咪唑-5-基甲基)-2(3H)-呋喃酮盐酸盐;氨噻唑;(+)-毛果芸香碱盐酸盐;
英文别名:(3S,4R);pilocel;Akarpine;Pilocarpine HCl;Salagen;pilocarpine,2(3H)-furanone,3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)-methyl] monohydrochloride,(3S-cis);2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, monohydrochloride, (3S-cis)-;(3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)-methyl]dihydrofuran-2(3H)one hydrochloride;pilovisc;Sanpilo;Pilocarpine (Hydrochloride);pilocar;ami-pilo;amisturap;pilocarpine HCl;
分子式:C11H17ClN2O2
分子量:244.718
精确质量:244.098
Psa:44.12
Logp:1.9638
编号系统
MDL号:MFCD00012722
物化性质
外观与性状:白色粉末
沸点:431.8ºC at 760mmHg
熔点:202-205°C(lit.)
闪点:215ºC
折射率:1.584
水溶解性:soluble
稳定性:Stable under normal shipping and handling conditions.
储存条件:2-8ºC
沸点:431.8ºC at 760mmHg
熔点:202-205°C(lit.)
闪点:215ºC
折射率:1.584
水溶解性:soluble
稳定性:Stable under normal shipping and handling conditions.
储存条件:2-8ºC
安全信息
RTECS号:TK1450000
安全说明:S25-S45
危险类别码:R26/28
WGK Germany:3
海关编码:2934999090
危险品运输编码:UN 1544 6.1/PG 3
危险类别:6.1
包装等级:III
危险品标志:T+
安全说明:S25-S45
危险类别码:R26/28
WGK Germany:3
海关编码:2934999090
危险品运输编码:UN 1544 6.1/PG 3
危险类别:6.1
包装等级:III
危险品标志:T+
生产方法及用途
用途
生化研究。
生化研究。
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图谱
Predict 1H proton NMR

13C NMR : Predict

1H NMR : Predict

Raman : 4880 A,200 M,powder

IR : nujol mull

IR : KBr disc
