Aminopterin (or 4-aminopteroic acid), the 4-amino derivative of folic acid, is an antineoplastic drug with immunosuppressive properties often used in chemotherapy. Aminopterin is a synthetic derivative of pterin. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effectively blocks tetrahydrofolate synthesis. This results in the depletion of nucleotide precursors and inhibition of DNA, RNA, and protein synthesis.

CAS：54-62-6
中文别名：4-氨基-PGA;4-安蝶林;氨喋呤水合物;氨基喋呤;4-氨基蝶酰-L-谷氨酸;白血宁;
英文别名：Aminoperin;apga;aminopteridin;AGPA;Aminopterin;Minopterin;pteramina;
分子式：C19H20N8O5
分子量：440.413
精确质量：440.156
Psa：219.33
Logp：1.8704

MDL号：MFCD00036692

外观与性状：黄色固体
密度：1.588g/cm3
熔点：228-235°C (dec.)
折射率：1.761
稳定性：Stable at normal temperatures and pressures.
储存条件：库房通风低温干燥

RTECS号：MA1050000
安全说明：S53-S28-S36/37-S45
WGK Germany：3
危险类别码：R61; R28
海关编码：3822009000
危险品运输编码：UN 2811 6.1/PG 1
危险类别：6.1(a)
包装等级：I
危险品标志：T+
危险性防范说明：P201; P264; P301 + P310; P308 + P313
信号词：Danger
危险性描述：H300; H360
危险标志：GHS06, GHS08

用途
抗肿瘤药。治疗牛皮癣皮肤病,也可用于治疗急性、亚急性儿童白血病。 生化研究。抗叶酸药。