Ammonium Glycyrrhizinate is used in the synthesis of polyion complex nanocarriers which may act as a template for the design of other negatively charged water-soluble drugs. Particularly for anti-inflammatory drugs with which Ammonium Glycyrrhizinate is associated.

CAS：53956-04-0
中文别名：甘草酸单铵水合物;甘草酸单铵盐;甘草酸一铵盐水合物;甘草酸单氨;
英文别名：glycyrrhizic acid monoammonium salt;Magnasweet;GLYCYRRHIZIC ACID,NH4;ammoniate;ammonium glycyrrhizinate;AMMONIUMGLYCYRRHIZIN;Ammoniumglycynhizinato;Glycyrrhizic Acid Monoammonium Salt Hydrate;ammoniumglycyrrhizate;Glycyrrhizin Monoammonium Salt Hydrate;Monoammonium Glycyrrhizinate Hydrate;Glycyrrhizin ammonium;GLYCYRRHIZICAMMONIUM;Glycyrrhizate monoammonium;Monoammoniumglycyrrhizinate;Ammonium glycyrrhizinate;Glycyrrhiz;GLYCAMIL;Ammonium glycyrrhizate;Glycyrrhizic acid monoammonium salt trihydrate;glycyrram;
分子式：C42H68N2O16
分子量：856.993
精确质量：856.457
Psa：272.7
Logp：0.3286

UNII：3VRD35U26C

外观与性状：白色结晶粉末
密度：1.43g/cm3
沸点：971.4ºC at 760mmHg
熔点：209ºC
闪点：288.1ºC
稳定性：Stable under normal temperatures and pressures.
储存条件：2-8ºC

生产方法
以甘草酸粗品(含量约50%,重量法)为原料,酸性乙醇为提取剂,精制而得。将50g甘草酸粗品加入盐酸酸化的95%的乙醇170mL(Ph值3.5～4.0),在40～50℃下搅拌提取4h。过滤后滤渣用100mL乙醇在同样条件下提取3h。合并提取液,搅拌下滴加氨水或通入氨气,使溶液Ph值为7.2～7.5,室温静置0.5h使完全沉淀。沉淀为甘草酸三铵盐,用适量的冰醋酸使之分散调成糊状,必要时微微加热,静置1h后过滤,使其转化为一铵盐。结晶分离后用少量的冰醋酸洗涤1～2次,得浅黄色粗品。用75%乙醇进行活性炭脱色重结晶,得白色结晶15.5g,收率61%,纯度≥98%。 医药行业用于止咳化痰、治疗肝病等。
用途
医药行业用于止咳化痰、治疗肝病等。