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化合物简介

Enoxolone (INN, BAN; also known as glycyrrhetinic acid or glycyrrhetic acid) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice. It is used in flavoring and it masks the bitter taste of drugs like aloe and quinine. It is effective in the treatment of peptic ulcer and also has expectorant (antitussive) properties. It has some additional pharmacological properties including antiviral, antifungal, antiprotozoal, and antibacterial activities.

基本信息

CAS:471-53-4
中文别名:甘草次酸(β型);(3β,20β)-3-羟基-11-氧代-齐墩果-12-烯-29-酸;
英文别名:ENOLOXONE;biosone;glycyrrhetin;Glycyrrhetic acid;STX 352;URALENIC ACID;Glycyrrhetic Acid;glycyrrhetinic acid;Arthrodont;GM 1658;PO 12;18β-Glycyrrhetinic acid;18-beta-Glycyrrhetinic acid;18b-Glycyrrhetic acid;
分子式:C30H46O4
分子量:470.684
精确质量:470.34
Psa:74.6
Logp:6.4126

编号系统

MDL号:MFCD00003706

物化性质

外观与性状:白色结晶粉末
密度:1.14g/cm3
沸点:588.3ºC at 760mmHg
熔点:292 - 295ºC
闪点:323.7ºC
稳定性:Stable under normal temperatures and pressures.
储存条件:Store in a cool, dry place. Store in a tightly closed container. Refrigerator (approx 4ºC).
蒸汽压:2.71E-16mmHg at 25°C

安全信息

安全说明:S22; S24/25
危险类别码:R22; R36
海关编码:2938909030
危险品标志:Xn

生产方法及用途

合成路线

  • 参考文献

    Baltina; Flekhter; Putieva; Kondratenko; Krasnova; Tolstikov Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 4 p. 263 - 266

上游原料

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图谱

1H NMR : Predict


13C NMR : Predict


13C NMR : in CDCl3


Mass


IR : KBr disc


IR : nujol mull


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