A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants.

CAS：53123-88-9
中文别名：西罗莫司;
英文别名：RPM;RAPA;RAPAMUNE;Rapamycin (Sirolimus);Rapamycin/Sirolimus;Rapamycin;RAPAMYCIN 1GM;SIROLIMUS;Rapamycin(Sirolimus);sila9268a;23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine,AY 22989,Sirolimus;RAPAMYCIN;Rapamycin from Streptomyces hygroscopicus;
分子式：C51H79NO13
分子量：914.172
精确质量：913.555
Psa：195.43
Logp：6.1185

UNII：W36ZG6FT64

外观与性状：黄色固体
密度：1.182 g/cm3
沸点：973.017ºC at 760 mmHg
熔点：183-185°C
闪点：542.261ºC
折射率：1.55
稳定性：Stable if stored as directed.
储存条件：-20ºC

安全说明：S22-S24/25
危险类别码：R36/38
海关编码：2942000000
危险品标志：Xi

用途
一种新型高效的免疫抑制剂，临床上用于器官移植的抗排斥反应和自身免疫性疾病的治疗。