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Demecolceine
(7S)-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
化合物简介
An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
基本信息
CAS：518-11-6
中文别名：
英文别名：Demecolcein;(S)-10-hydroxy-1,2,3-trimethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-one;demecolceine;(S)-10-Hydroxy-1,2,3-trimethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-on;N-Desacetyl-N-methylcolchiceine;(7s)-9-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-10(5h)-one;
分子式：C20H23NO5
分子量：357.4
精确质量：357.158
Psa：77.02
Logp：3.0428
中文别名：
英文别名：Demecolcein;(S)-10-hydroxy-1,2,3-trimethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-one;demecolceine;(S)-10-Hydroxy-1,2,3-trimethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-on;N-Desacetyl-N-methylcolchiceine;(7s)-9-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-10(5h)-one;
分子式：C20H23NO5
分子量：357.4
精确质量：357.158
Psa：77.02
Logp：3.0428
编号系统
物化性质
密度：1.27g/cm3
沸点：626.4ºC at 760 mmHg
闪点：332.6ºC
折射率：1.608
沸点：626.4ºC at 760 mmHg
闪点：332.6ºC
折射率：1.608
安全信息
生产方法及用途
合成路线
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参考文献
Kiselew; Men'schikow Doklady Akademii Nauk SSSR, 1953 , vol. 88, p. 825 Chem.Abstr., 1954 , p. 3952 Full Text Show Details Santavy Collection of Czechoslovak Chemical Communications, 1951 , vol. 16/17, p. 676,683 Full Text Show Details Uffer et al. Helvetica Chimica Acta, 1954 , vol. 37, p. 18,29 Full Text Show Details Ueno Yakugaku Zasshi, 1953 , vol. 73, p. 1232,1233 Proceedings of the Japan Academy, 1953 , vol. 29, p. 266,269
上游原料
下游产品
图谱
13C NMR : Predict
1H NMR : Predict
