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7-Methoxy-2-methyl-1-[2-(4-morpholinyl)ethyl]-N-[(1S,2S,4R)-1,3,3 -trimethylbicyclo[2.2.1]hept-2-yl]-1H-indole-3-carboxamide
化合物简介
MN-25 (UR-12) is a drug invented by Bristol-Myers Squibb, that acts as a reasonably selective agonist of peripheral cannabinoid receptors. It has moderate affinity for CB2 receptors with a Ki of 11nM, but 22x lower affinity for the psychoactive CB1 receptors with a Ki of 245nM. The indole 2-methyl derivative has the ratio of affinities reversed however, with a Ki of 8nM at CB1 and 29nM at CB2, which contrasts with the usual trend of 2-methyl derivatives having increased selectivity for CB2 (cf. JWH-018 vs JWH-007, JWH-081 vs JWH-098).
基本信息
CAS：501927-29-3
中文别名：
英文别名：
分子式：C27H39N3O3
分子量：453.617
精确质量：453.299
Psa：59.22
Logp：4.7478
中文别名：
英文别名：
分子式：C27H39N3O3
分子量：453.617
精确质量：453.299
Psa：59.22
Logp：4.7478
编号系统
物化性质
密度：1.2±0.1g/cm3
沸点：618.9±55.0°Cat760mmHg
闪点：328.1±31.5°C
蒸汽压：0.0±1.8mmHgat25°C
折射率：1.620
沸点：618.9±55.0°Cat760mmHg
闪点：328.1±31.5°C
蒸汽压：0.0±1.8mmHgat25°C
折射率：1.620
安全信息
生产方法及用途
合成路线
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参考文献
Hynes Jr., John; Leftheris, Katerina; Wu, Hong; Pandit, Chennagiri; Chen, Ping; Norris, Derek J.; Chen, Bang-Chi; Zhao, Rulin; Kiener, Peter A.; Chen, Xiaorong; Turk, Lori A.; Patil-Koota, Vina; Gillooly, Kathleen M.; Shuster, David J.; McIntyre, Kim W. Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 17 p. 2399 - 2402
上游原料
下游产品
图谱
13C NMR : Predict
1H NMR : Predict
