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化合物简介
1,4’-Bipiperidine is used in the synthesis of selective sphingosine kinase 1 inhibitors used as a therapeutic agent for proliferative diseases. Also used in the synthesis of calcitonin gene-related (CGRP) receptor antagonists.
基本信息
CAS：4897-50-1
中文别名：派啶基派啶;1,4\'-二哌啶;N-(4-哌啶基)哌啶;4-(1-哌啶基)哌啶;4-哌啶并哌啶;
英文别名：1-piperidin-4-ylpiperidine;4-Piperidinopiperidine;1,4\'-Bipiperidine;
分子式：C10H20N2
分子量：168.279
精确质量：168.163
Psa：15.27
Logp：1.491
中文别名：派啶基派啶;1,4\'-二哌啶;N-(4-哌啶基)哌啶;4-(1-哌啶基)哌啶;4-哌啶并哌啶;
英文别名：1-piperidin-4-ylpiperidine;4-Piperidinopiperidine;1,4\'-Bipiperidine;
分子式：C10H20N2
分子量：168.279
精确质量：168.163
Psa：15.27
Logp：1.491
编号系统
MDL号：MFCD00006475
物化性质
外观与性状：白色或略黄色晶体
密度：0.969 g/cm3
沸点：251.4ºC at 760 mmHg
熔点：64-66°C(lit.)
闪点：99.9ºC
稳定性：Stable at room temperature in closed containers under normal storage and handling conditions.
储存条件：Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
密度：0.969 g/cm3
沸点：251.4ºC at 760 mmHg
熔点：64-66°C(lit.)
闪点：99.9ºC
稳定性：Stable at room temperature in closed containers under normal storage and handling conditions.
储存条件：Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
安全信息
安全说明：S26-S36-S24/25
WGK Germany：3
危险类别码：R36/37/38
海关编码：2933399090
危险品标志：Xi
WGK Germany：3
危险类别码：R36/37/38
海关编码：2933399090
危险品标志：Xi
生产方法及用途
合成路线
-
参考文献
Hicks, Latorya D.; Hyatt, Janice L.; Stoddard, Shana; Tsurkan, Lyudmila; Edwards, Carol C.; Wadkins, Randy M.; Potter, Philip M. Journal of Medicinal Chemistry, 2009 , vol. 52, # 12 p. 3742 - 3752
上游原料
下游产品
图谱
Predict 1H proton NMR
13C NMR : Predict
1H NMR : Predict
13C NMR : in CDCl3
Mass
IR : nujol mull
IR : KBr disc
