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化合物简介
Carbinoxamine (Clistin, Palgic, Rondec, Rhinopront) is a antihistamine and anticholinergic agent. It was first launched in the United States by the McNeil Corporation under the brand name Clistin. It is now available under the brand name Palgic as 4 mg tablets or 4 mg/5 mL liquid. It is approved by the U.S. Food and Drug Administration (FDA) (specifically at the 4 mg dose/strength) for hay fever (a.k.a. allergic rhinitis, SAR and PAR); vasomotor rhinitis; mild urticaria; angioedema, dermatographism and allergic conjunctivitis. Carbinoxamine is a histamine antagonist, specifically an H1-antagonist. The maleic acid salt of the levorotatory isomer is sold as the prescription drug rotoxamine.
基本信息
CAS:486-16-8
中文别名:2-[(4-氯苯基)(吡啶-2-基)甲氧基]-N,N-二甲基乙胺;氯苯吡醇胺;
英文别名:Carbinoxamina;2-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-N,N-dimethylethanamine;Rotoxamine;2-((4-Chlorophenyl)(pyridin-2-yl)methoxy)-N,N-dimethylethanamine;Carbinoxaminum;Clistin;(+/-)-Carbinoxamine;McN-R 73Z;Allergefon;
分子式:C16H19ClN2O
分子量:290.788
精确质量:290.119
Psa:25.36
Logp:3.4026
中文别名:2-[(4-氯苯基)(吡啶-2-基)甲氧基]-N,N-二甲基乙胺;氯苯吡醇胺;
英文别名:Carbinoxamina;2-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-N,N-dimethylethanamine;Rotoxamine;2-((4-Chlorophenyl)(pyridin-2-yl)methoxy)-N,N-dimethylethanamine;Carbinoxaminum;Clistin;(+/-)-Carbinoxamine;McN-R 73Z;Allergefon;
分子式:C16H19ClN2O
分子量:290.788
精确质量:290.119
Psa:25.36
Logp:3.4026
编号系统
UNII:982A7M02H5
物化性质
密度:1.143g/cm3
沸点:381.1ºC at 760mmHg
闪点:184.3ºC
沸点:381.1ºC at 760mmHg
闪点:184.3ºC
安全信息
海关编码:2933399090
生产方法及用途
合成路线
上游原料
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图谱
13C NMR : Predict

1H NMR : Predict
