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化合物简介
Oroxylin A is an O-methylated flavone, a chemical compound that can be found in the medicinal plant Scutellaria baicalensis and the Oroxylum indicum tree. It has demonstrated activity as a dopamine reuptake inhibitor, and is also a negative allosteric modulator of the benzodiazepine site of the GABAA receptor. Oroxylin A has been found to improve memory consolidation in mice by elevating brain-derived neurotrophic factor (BDNF) levels in the hippocampus.
基本信息
CAS：480-11-5
中文别名：千层纸素;木蝴蝶素A;
英文别名：5,7-dihydroxy-6-methoxyflavone;6-Methoxybaicalein;oroxyllin-A;5,7-dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one;Oroxylin;4H-1-Benzopyran-4-one, 5,7-dihydroxy-6-methoxy-2-phenyl-;6-methoxy-5,7-dihydroxyflavone;5,7-Dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one 5,7-Dihydroxy-6-methoxyflavone;5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one;baicalein 6-methyl ether;Oroxylin A;4H-1-Benzopyran-4-one,5,7-dihydroxy-6-methoxy-2-phenyl;
分子式：C16H12O5
分子量：284.263
精确质量：284.068
Psa：79.9
Logp：2.8798
中文别名：千层纸素;木蝴蝶素A;
英文别名：5,7-dihydroxy-6-methoxyflavone;6-Methoxybaicalein;oroxyllin-A;5,7-dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one;Oroxylin;4H-1-Benzopyran-4-one, 5,7-dihydroxy-6-methoxy-2-phenyl-;6-methoxy-5,7-dihydroxyflavone;5,7-Dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one 5,7-Dihydroxy-6-methoxyflavone;5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one;baicalein 6-methyl ether;Oroxylin A;4H-1-Benzopyran-4-one,5,7-dihydroxy-6-methoxy-2-phenyl;
分子式：C16H12O5
分子量：284.263
精确质量：284.068
Psa：79.9
Logp：2.8798
编号系统
物化性质
密度：1.42g/cm3
沸点：540.9ºC at 760mmHg
熔点：195-197ºC
闪点：207.4ºC
折射率：1.668
蒸汽压：2.6E-12mmHg at 25°C
沸点：540.9ºC at 760mmHg
熔点：195-197ºC
闪点：207.4ºC
折射率：1.668
蒸汽压：2.6E-12mmHg at 25°C
安全信息
生产方法及用途
合成路线
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参考文献
Unitech Pharmaceuticals, Inc. Patent: US2004/242907 A1, 2004 ; Location in patent: Page 3 ;
上游原料
下游产品
图谱
13C NMR : Predict
1H NMR : Predict
