化学科研者一站式服务平台
化合物简介
Eseroline is a drug which acts as an opioid agonist. It is a metabolite of the acetylcholinesterase inhibitor physostigmine but unlike physostigmine, the acetylcholinesterase inhibition produced by eseroline is weak and easily reversible, and it produces fairly potent analgesic effects mediated through the μ-opioid receptor. This mixture of activities gives eseroline an unusual pharmacological profile, although its uses are limited by side effects such as respiratory depression and neurotoxicity.
基本信息
CAS:469-22-7
中文别名:
英文别名:Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, (3aS-cis)-;(S)-(-)-4\',7-Isoflavandiol;(+/-)-Equol;7-hydroxy-3-(4-hydroxyphenyl)-1-benzopyran;3,4-dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol;1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-ol;(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-ol;4\',7-DIHYDROXYISOFLAVAN;R,S-EQUOL;(3S)-Equol;7,4\'-ISOFLAVANDIOL;EQUOL/()-4\'\',7-ISOFLAVANDIOL;(S)-EQUOL;(3AS-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]-indol-5-ol;(-)-Eseroline;1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indol-5-ol;4\',7-ISOFLAVANDIOL;EQUOL,(+/-)-(SH);
分子式:C13H18N2O
分子量:218.295
精确质量:218.142
Psa:26.71
Logp:1.7642
中文别名:
英文别名:Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, (3aS-cis)-;(S)-(-)-4\',7-Isoflavandiol;(+/-)-Equol;7-hydroxy-3-(4-hydroxyphenyl)-1-benzopyran;3,4-dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol;1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-ol;(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-ol;4\',7-DIHYDROXYISOFLAVAN;R,S-EQUOL;(3S)-Equol;7,4\'-ISOFLAVANDIOL;EQUOL/()-4\'\',7-ISOFLAVANDIOL;(S)-EQUOL;(3AS-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]-indol-5-ol;(-)-Eseroline;1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indol-5-ol;4\',7-ISOFLAVANDIOL;EQUOL,(+/-)-(SH);
分子式:C13H18N2O
分子量:218.295
精确质量:218.142
Psa:26.71
Logp:1.7642
编号系统
物化性质
密度:1.16g/cm3
沸点:366.3ºC at 760mmHg
闪点:189.6ºC
折射率:1.597
蒸汽压:6.99E-06mmHg at 25°C
沸点:366.3ºC at 760mmHg
闪点:189.6ºC
折射率:1.597
蒸汽压:6.99E-06mmHg at 25°C
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
13C NMR : Predict

1H NMR : Predict
