Aurintricarboxylic acid (ATA) is a chemical compound that readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. It also inhibits apoptosis. It prevents down-regulation of Ca2+-impermeable GluR2 receptors and inhibits calpain, a Ca2+-activated protease that is activated during apoptosis.

CAS：4431-00-9
中文别名：金黄三羧酸;金黄三羧羧;
英文别名：AURINTRICARBOXYLIC ACID;Aurintricarboxylic Acid;Aurintricarboxylic acid;
分子式：C22H14O9
分子量：422.341
精确质量：422.064
Psa：169.43
Logp：2.446

EINECS号：224-628-1

密度：1.65g/cm3
沸点：759.6ºC at 760mmHg
熔点：300°C(lit.)
闪点：427.1ºC
折射率：1.751

RTECS号：GU4790000
安全说明：S26-S36
WGK Germany：3
危险类别码：R36/37/38
危险品标志：Xi

生产方法
水杨酸与甲醛反应得到亚甲基二水杨酸,再将其与水杨酸、亚硝酰硫酯混合反应,得金黄三羧酸。 广泛用作强有力细胞生长抑制剂(是由于形成蛋白质核酸络合物)。 铝试剂的中间体。
用途
广泛用作强有力细胞生长抑制剂(是由于形成蛋白质核酸络合物)。 铝试剂的中间体。