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化合物简介

Flumequine is a synthetic fluoroquinolone antibiotic used to treat bacterial infections. It is a first-generation fluoroquinolone antibacterial that has been removed from clinical use and is no longer being marketed. It kills bacteria by interfering with the enzymes that cause DNA to unwind and duplicate. Flumequine was used in veterinarian medicine for the treatment of enteric infections (all infections of the intestinal tract), as well as to treat cattle, swine, chickens, and fish, but only in a limited number of countries. It was occasionally used in France (and a few other European Countries) to treat urinary tract infections under the trade name Apurone. However this was a limited indication because only minimal serum levels were achieved.

基本信息

CAS:42835-25-6
中文别名:9-氟-6,7-二氢-5-甲基-1-氧代-1H,5H-苯并(ij)喹嗪-2-羧酸;9-氟-1,5,6,7-四氢-5-甲基-1-氧代吡啶并[3,2,1-ij]喹啉-2-羧酸;
英文别名:Aoyribe;Flumural;Apurone;9-Fluoro-5-methyl-1-oxo-1,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxylic acid;R 802;Quinolone;Imequyl;FLUMEQUIN;Fantacin;9-Fluoro-1,5,6,7-tetrahydro-5-methyl-1-oxopyrido[3,2,1-ij]quinoline-2-carboxylic Acid;Flumeguine;
分子式:C14H12FNO3
分子量:261.248
精确质量:261.08
Psa:59.3
Logp:2.346

编号系统

UNII:UVG8VSP2SJ

物化性质

外观与性状:白色至灰白色粉末
密度:1.45 g/cm3
沸点:439.7ºC at 760 mmHg
熔点:253-255°C
闪点:219.7ºC
折射率:1.645
稳定性:Stable. Incompatible with strong oxidizing agents.
储存条件:0-6ºC

安全信息

安全说明:S22-S24/25
WGK Germany:3
危险类别码:R36/37/38
海关编码:2933990090
危险类别:6.1
危险品标志:Xi

生产方法及用途

用途
喹诺酮类产品的第二代抗菌剂,有很强的杀菌活力,对动物。

合成路线

上游原料

下游产品

图谱

Predict 1H proton NMR


13C NMR : Predict


1H NMR : Predict


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