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化合物简介
Piperaquine is an antimalarial drug, a bisquinoline first synthesised in the 1960s, and used extensively in China and Indochina as prophylaxis and treatment during the next 20 years. Usage declined in the 1980s as piperaquine-resistant strains of P. falciparum arose and artemisinin-based antimalarials became available. However, Chinese scientists have been studying whether piperaquine can still be used therapeutically in combination with artemisinin.
基本信息
CAS：4085-31-8
中文别名：1,3-双[4-(7-氯-喹啉-4-基)哌嗪-1-基]丙烷四磷酸盐四水合物;
英文别名：Piperaquine tetraphosphate tetrahydrate;7-Chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline;piperaquinoline;PIRERAQUINE PHOSPHATE;Piperaquine;
分子式：C29H32Cl2N6
分子量：535.511
精确质量：534.207
Psa：38.74
Logp：5.4299
中文别名：1,3-双[4-(7-氯-喹啉-4-基)哌嗪-1-基]丙烷四磷酸盐四水合物;
英文别名：Piperaquine tetraphosphate tetrahydrate;7-Chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline;piperaquinoline;PIRERAQUINE PHOSPHATE;Piperaquine;
分子式：C29H32Cl2N6
分子量：535.511
精确质量：534.207
Psa：38.74
Logp：5.4299
编号系统
物化性质
密度：1.292g/cm3
沸点：721.1ºC at 760 mmHg
闪点：389.9ºC
折射率：1.664
沸点：721.1ºC at 760 mmHg
闪点：389.9ºC
折射率：1.664
安全信息
海关编码：2942000000
生产方法及用途
合成路线
-
参考文献
MATRIX LABORATORIES LTD.; SETHI, Madhuresh, Kumar; RAWAT, Vijendra, Singh; AYYARAN, Karthikeyan; YERRAMALLA, Raja, Krishna; BONTALAKOTI, Jagan, Mohan, Rao; VEMULA, Lakshminarayana; NIMMAGADDA, Anitha; DATTA, Debashish Patent: WO2011/95885 A1, 2011 ; Location in patent: Page/Page column 11 ;
上游原料
下游产品
图谱
1H NMR : Predict
13C NMR : Predict
