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化合物简介

GW3965 is a potent, selective liver X receptor (LXR) agonist for hLXRα and hLXR. GW3965 has shown potent anti-inflammatory activity in both irritant and allergic contact models of dermatitis, requiring the participation of both LXRα and LXRβ.

基本信息

CAS:405911-09-3
中文别名:3-[3-[[[2-氯-3-(三氟甲基)苯基]甲基](2,2-联苯基乙基)氨基]丙氧基]苯乙酸盐酸盐;3-[3-[[[2-氯-3-(三氟甲基)苯基]甲基](2,2-二苯基乙基)氨基]丙氧基]-苯乙酸;GW-3965;
英文别名:UNII-6JI5YOG7RC;3-(3-(N-(2-Chloro-3-trifluoromethylbenzyl)(2,2-diphenylethyl)amino)propoxy)phenylacetic acid;(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-acetic acid;(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-acetic acid;2-(3-{3-[[2-chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy}-phenyl)acetic acid;2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]propoxy]phenyl]acetic acid;2-(3-(3-((2-chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)propoxy)phenyl)acetic acid;3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-N-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid;2-{3-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)amino)propoxy]phenyl}acetic acid;
分子式:C33H31ClF3NO3
分子量:582.052
精确质量:581.194
Psa:49.77
Logp:8.0891

编号系统

UNII:6JI5YOG7RC

物化性质

密度:1.261g/cm3
沸点:672.4ºC at 760mmHg
闪点:360.5ºC

安全信息

生产方法及用途

合成路线

上游原料

下游产品

图谱

1H NMR : Predict


13C NMR : Predict


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