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化合物简介
Telaprevir (VX-950), marketed under the brand names Incivek and Incivo, is a pharmaceutical drug for the treatment of hepatitis C codeveloped by Vertex Pharmaceuticals and Johnson & Johnson. It is a member of a class of antiviral drugs known as protease inhibitors. Specifically, telaprevir inhibits the hepatitis C viral enzyme NS3.4A serine protease. Telaprevir is only indicated for use against hepatitis C genotype 1 viral infections and has not been proven to have an effect on or being safe when used for other genotypes of the virus. The standard therapy of pegylated interferon and ribavirin is less effective on genotype 1.
基本信息
CAS:402957-28-2
中文别名:特拉匹伟;TELAPREVIR;特拉匹伟/VX950;
英文别名:VX-950;Telaprevir;Telaprevir (VX-950);
分子式:C36H53N7O6
分子量:679.849
精确质量:679.406
Psa:179.56
Logp:3.9474
中文别名:特拉匹伟;TELAPREVIR;特拉匹伟/VX950;
英文别名:VX-950;Telaprevir;Telaprevir (VX-950);
分子式:C36H53N7O6
分子量:679.849
精确质量:679.406
Psa:179.56
Logp:3.9474
编号系统
UNII:655M5O3W0U
物化性质
密度:1.25 g/cm3
安全信息
生产方法及用途
用途
治疗丙肝病毒(HCV)感染
治疗丙肝病毒(HCV)感染
合成路线
-
参考文献
WO2011/103932 A1, ; Page/Page column 50; 51 ;
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图谱
Predict 1H proton NMR






