Aphidicolin is a tetracyclic diterpene antibiotic isolated from the fungus, Cephalosporum aphidicola with antiviral and antimitotic properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. It blocks the cell cycle at early S phase. It is a specific inhibitor of DNA polymerase A,D in eukaryotic cells and in some viruses (vaccinia and herpesviruses) and an apoptosis inducer in HeLa cells. Natural aphidicolin is a secondary metabolite of the fungus Nigrospora oryzae.

CAS：38966-21-1
中文别名：阿非迪霉素;艾菲地可宁, 来源于黑曲霉;
英文别名：APC;9-dimethanol,tetradecahydro-3,9-11a-methano-11ah-cyclohepta(a)naphthalene-4;Aphidicolin from Nigrospora sphaerica;Apchidicolin;Aphidicholin;Aphidicolin, 98%, from Nigrospora oryzae;aphidocolin;
分子式：C20H34O4
分子量：338.482
精确质量：338.246
Psa：80.92
Logp：2.0858

UNII：192TJ6PP19

外观与性状：白色至灰白色粉末
密度：1.22 g/cm3
沸点：507.8ºC at 760 mmHg
熔点：225-233ºC
闪点：230.4ºC
折射率：1.586
储存条件：2-8ºC

安全说明：S22-S24

用途
细胞增生和分化研究中的生物工具。DNA聚合酶抑制剂。抗肿瘤和抗有丝分裂的抗生素。