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化合物简介

Ciclazindol (WY-23,409) is an antidepressant and anorectic drug of the tetracyclic chemical class that was developed in the mid to late 1970s, but was never marketed. It acts as a norepinephrine reuptake inhibitor, and to a lesser extent as a dopamine reuptake inhibitor. Ciclazindol has no effects on the SERT, 5-HT receptors, mACh receptors, or α-adrenergic receptors, and has only weak affinity for the H1 receptor. As suggested by its local anesthetic properties, ciclazindol may also inhibit sodium channels. It is known to block potassium channels as well.

基本信息

CAS:37751-39-6
中文别名
英文别名:10-(3-chlorophenyl)-2,3,4,10-tetrahydropyrimido[1,2-a]indol-10-ol;10-(m-Chlorophenyl)-2,3,4,10-tetrahydropyrimido<1,2-a>indol-10-ol;
分子式:C17H15ClN2O
分子量:298.767
精确质量:298.087
Psa:35.83
Logp:2.6987

编号系统

UNII:Y3I9520J7P

物化性质

密度:1.35g/cm3
沸点:475.4ºC at 760 mmHg
闪点:241.3ºC
折射率:1.687

安全信息

海关编码:2933990090

生产方法及用途

合成路线

上游原料

下游产品

图谱

13C NMR : Predict


1H NMR : Predict


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