Perfluorobutanesulfonyl fluoride (nonafluorobutanesulfonyl fluoride, NfF) is a colorless, volatile liquid that is immiscible with water but soluble in common organic solvents. It is prepared by the electrochemical fluorination of sulfolane. NfF serves as an entry point to nonafluorobutanesulfonates (nonaflates), which are valuable as electrophiles in palladium catalyzed cross coupling reactions. As a perfluoroalkylsulfonylating agent, NfF offers the advantages of lesser cost and greater stability over the more frequently used triflic anhydride. The fluoride leaving group is readily substituted by nucleophiles such as amines, phenoxides, and enolates, giving sulfonamides, aryl nonaflates, and alkenyl nonaflates respectively. However, it is not attacked by water (in which it is stable at pH<12). Hydrolysis by barium hydroxide gives Ba(ONf)2, which upon treatment with sulfuric acid gives perfluorobutanesulfonic acid and insoluble barium sulfate.

CAS：375-72-4
中文别名：九氟-1-丁烷磺酰基氟化物;1,1,2,2,3,3,4,4,4-九氟-1-丁烷磺酰氟;九氟丁烷磺酰氟;全氟-1-丁基磺酰基氟化物;FX-4;
英文别名：1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonyl fluoride;Nonafluoro-1-butanesulfonyl Fluoride;Perfluoro-1-butanesulfonyl Fluoride;1,1,2,2,3,3,4,4,4-Nonafluorobutane-1-sulfonyl fluoride;Nonafluorobutanesulfonyl Fluoride;
分子式：C4F10O2S
分子量：302.091
精确质量：301.946
Psa：42.52
Logp：3.7922

MDL号：MFCD00007422

外观与性状：透明无色或略黄色液体
密度：1.716g/mLat 20°C(lit.)
沸点：64°C(lit.)
熔点：-110°C
闪点：65-66°C
折射率：n20/D 1.3(lit.)

安全说明：S26-S36/37/39-S45-S25
WGK Germany：3
危险类别码：R34
危险品运输编码：UN 3265 8/PG 2
海关编码：2942000000
危险类别：8
包装等级：II
危险品标志：C

用途
本品结构性能类似于全氟辛磺酰氟，可以用来合成多种含氟特种表面活性剂。用于合成氟碳表面活性剂、含氟农药、染料、聚碳酸酯加工处理分散剂,又是聚碳酸酯最佳阻燃剂。