Zebularine is a nucleoside analog of cytidine. It is a \"transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.\"; In a small study of mice with a defective Adenomatous polyposis coli gene, oral administration of zebularine to males had no effect on the overall methylation of DNA or the number of polyps, but in females the average number of polyps was reduced from 58 to 1. It has therefore been suggested for drug use as a prototype of epigenetic therapy for cancer chemoprevention.

CAS：3690-10-6
中文别名：泽布拉林;
英文别名：2(1H)-Pyrimidinone, 1-.β.-D-ribofuranosyl-;[14C]-Zebularine;4-Deoyuridine;2(1H)-PyriMidinone,1-b-D-ribofuranosyl;1--D-Ribofuranosyl-2(1H)-pyrimidinone;Zebularine;4-Deoxyuridine;Pyrimidin-2-one-D-Ribofuranoside;
分子式：C9H12N2O5
分子量：228.202
精确质量：228.075
Psa：104.81
Logp：-2.1452

UNII：7A9Y5SX0GY

密度：1.7±0.1g/cm3
沸点：499.0±55.0°Cat760mmHg
熔点：160-162?C
闪点：255.6±31.5°C
外观性状：solid
蒸汽压：0.0±2.9mmHgat25°C
折射率：1.697
储存条件：2-8°C
水溶解性：DMSO:16 mg/mL,soluble