4-Fluoro-3-chloroaniline, is an organic Fluorinated building block used for the synthesis of pharmaceutical and biologically active compounds such as, novel 6-Fluorobenzothiazole-substituted pyrazole analogues, having antiinflammatory activity.

CAS：367-21-5
中文别名：4-氟-3-氯苯胺;3-氨基-6-氟氯苯;氟氯苯胺;吉非替尼杂质V;
英文别名：para-fluoro-meta-chloroaniline;3-chloro-4-fluoroanilline;Benzenamine, 3-chloro-4-fluoro-;3-chlor-4-fluoranilin;3-Chloro-4-fluorobenzenamine;3-Cl-4-F-aniline;Benzenamine,3-chloro-4-fluoro;3-Chloro-4-fluorophenylamine;4-fluoro-3-chloro-aniline;Aniline,3-chloro-4-fluoro;CHLOROFLUOROANILINE;3-chloro-4-fluoro aniline;
分子式：C6H5ClFN
分子量：145.562
精确质量：145.009
Psa：26.02
Logp：2.6425

MDL号：MFCD00007767

外观与性状：白色结晶粉末
密度：1,226 g/cm3
沸点：227-228°C(lit.)
熔点：42-44°C(lit.)
闪点：>230°F
折射率：1.54-1.542
水溶解性：10 g/L (20 ºC)
稳定性：Stable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, chloroformates. May be air-sensitive.
储存条件：Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Do not expose to air. Store under an inert atmosphere.

安全说明：S36/37/39-S45-S26
WGK Germany：2
危险类别码：R23/24/25; R33
危险品运输编码：UN 2811 6.1/PG 2
海关编码：29214210
包装等级：III
危险品标志：T
危险标志：GHS06, GHS08
危险性防范说明：P261; P280; P301 + P310; P311
危险性描述：H301 + H311 + H331; H373
信号词：Danger

生产方法
以邻二氯苯为原料,经硝酸硝化、氢气还原而得。 氟罗沙星、诺氟沙星、洛美沙星等中间体。
用途
氟罗沙星、诺氟沙星、洛美沙星等中间体。