A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 µM). Shown to specifically block NF-kB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF.

CAS：354812-17-2
中文别名：
英文别名：4-Amino-[2,3\"]bithiophenyl-5-carboxylic acid amide;SC-514;IKK-2 Inhibitor,SC-514;4-amino-2,3\'-bithiophene-5-carboxamide;
分子式：C9H8N2OS2
分子量：224.303
精确质量：224.008
Psa：125.59
Logp：3.4392

密度：1.45g/cm3
沸点：399.2ºC at 760 mmHg
闪点：195.2ºC
折射率：1.715

危险性描述：H301
信号词：Danger
危险标志：GHS06
危险性防范说明：P301 + P310