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  • 2'-amino-5'-hydroxypropiophenone

化合物简介

1-(2-Amino-5-hydroxyphenyl)propan-1-one is a useful synthetic intermediate. It is used in the asymmetrical synthesis of (S)-4-ethyl-6,7,8,10- tetrahydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione, a key intermediate for synthesis of irinotecan and other camptothecin analogs. It is also used in the synthesis of E-​ring-​modified (RS)​-​camptothecin analogs as antitumor agents.

基本信息

CAS:35364-15-9
中文别名
英文别名:2-AMINO-5-HYDROXYPROPHENONE;.AHPP;2-amino-5-hydroxy-propiophenone;.AHP;1-(2-AMINO-5-HYDROXYPHENYL)PROPAN-1-ONE;.1-(2-amino-5-hydroxyphenyl)propan-1-one;.2-amino-5-hydroxypropiophenone;.2-amino-5 hydroxypropiophenone;
分子式:C9H11NO2
分子量:165.189
精确质量:165.079
Psa:63.32
Logp:2.1483

编号系统

物化性质

安全信息

生产方法及用途

合成路线

  • 参考文献

    Kabushiki Kaisha Yakult Honsha Patent: EP1378505 A1, 2004 ; Location in patent: Page 22-23 ;

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图谱

1H NMR : Predict


13C NMR : Predict


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