Flumexadol (INN) (developmental code name CERM-1841 or 1841-CERM) is a drug described and researched as a non-opioid analgesic which was never marketed. It has been found to act as an agonist of the serotonin 5-HT1A (pKi = 7.1) and 5-HT2C (pKi = 7.5) receptors and, to a much lesser extent, of the 5-HT2A (pKi = 6.0) receptor. According to Nilsson (2006) in a paper on 5-HT2C receptor agonists as potential anorectics, \"The (+)-enantiomer of this compound showed [...] affinity for the 5-HT2C receptor (Ki) 25 nM) [...] and was 40-fold selective over the 5-HT2A receptor in receptor binding studies. Curiously, the racemic version [...], also known as 1841 CERM, was originally reported to possess analgesic properties while no association with 5-HT2C receptor activity was mentioned.\" It is implied that flumexadol might be employable as an anorectic in addition to analgesic. Though flumexadol itself has never been approved for medical use, oxaflozane (brand name Conflictan) is a prodrug of the compound that was formerly used clinically in France as an antidepressant and anxiolytic agent.

CAS：30914-89-7
中文别名：
英文别名：1841CERM;Flumexadolum [INN-Latin];2-(3-(Trifluoromethyl)phenyl)morpholine;2-(3-Trifluormethylphenyl)-1,4-tetrahydro-oxazin;2-<3-(Trifluormethyl)-phenyl>-tetrahydro-1,4-oxazin;CERM-1841;Flumexadol;
分子式：C11H12F3NO
分子量：231.214
精确质量：231.087
Psa：21.26
Logp：2.6951

密度：1.209g/cm3
沸点：271.5ºC at 760mmHg
闪点：118ºC
折射率：1.464

海关编码：2934999090