HT-2157 (former code name SNAP-37889) is a drug which acts as a selective non-peptide antagonist for the receptor GAL-3, which is usually activated by the neuropeptide galanin. Blocking this receptor with HT-2157 produced increased serotonin release, as well as producing antidepressant and anxiolytic effects in animal studies, and it was also being researched for treatment of cognitive dysfunction. All human clinical trials were terminated due to safety concerns however, and new GAL-3 antagonists are now being sought instead.

CAS：303149-14-6
中文别名：
英文别名：1-phenyl-3-[[3-(trifluoromethyl)phenyl]imino]-1,3-dihydro-2H-indol-2-one;1-phenyl-3-[[3-(trifluoromethyl)-phenol]-imino]-1H-indol-2-one;1,3-dihydro-1-phenyl-3-[[3-trifluoromethylphenyl]imino]-2H-indol-2-one;1-phenyl-3-{[3-(trifluoromethyl)phenyl]azamethylene}benzo[d]azolidin-2-one;
分子式：C21H13F3N2O
分子量：366.336
精确质量：366.098
Psa：32.67
Logp：5.5695

储存条件：2-8℃