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化合物简介
5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is an intermediate in the generation of inosine monophosphate. AICAR is an analog of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent protein kinase (AMPK) activity. AICAR has been used clinically to treat and protect against cardiac ischemic injury. The drug was first used in the 1980s as a method to preserve blood flow to the heart during surgery. Currently, the drug has also been shown as a potential treatment for diabetes by increasing the metabolic activity of tissues by changing the physical composition of muscle.
基本信息
CAS：3031-94-5
中文别名：5-氨基咪唑-4-甲酰胺-1-Β-D-呋喃核糖苷5-一磷酸盐;
英文别名：Acadesine 5‘-phosphate;5\'-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-β-D-RIBOFURANOSYL 5\'-MONOPHOSPHATE;
分子式：C9H15N4O8P
分子量：338.211
精确质量：338.063
Psa：213.19
Logp：-1.4258
中文别名：5-氨基咪唑-4-甲酰胺-1-Β-D-呋喃核糖苷5-一磷酸盐;
英文别名：Acadesine 5‘-phosphate;5\'-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-β-D-RIBOFURANOSYL 5\'-MONOPHOSPHATE;
分子式：C9H15N4O8P
分子量：338.211
精确质量：338.063
Psa：213.19
Logp：-1.4258
编号系统
UNII：F0X88YW0YK
物化性质
外观与性状：白色粉末带有粉红色
密度：2.3g/cm3
沸点：845.3ºC at 760 mmHg
熔点：198-202ºC dec.
闪点：465ºC
折射率：1.831
储存条件：-20ºC
密度：2.3g/cm3
沸点：845.3ºC at 760 mmHg
熔点：198-202ºC dec.
闪点：465ºC
折射率：1.831
储存条件：-20ºC
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
13C NMR : Predict
1H NMR : Predict
