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化合物简介
2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide, is a precursor in the synthesis of Dasatinib, a protein tyrosine kinase inhibitor, and also for 2-Amino-thiazole-5-carboxylic Acid Phenylamide Derivatives, used as potent and selective anti-tumor drugs.
基本信息
CAS:302964-24-5
中文别名:2-氨基-N-(2-氯-6-甲基苯基)-5-噻唑酰胺;
英文别名:2-amino-N-(2-cliloro-6-metliylplienyl)thiazole-5-carboxamide;2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide;2-AMINO-N-(2-CHLORO-6-METHYLPHENYL)THIAZOLE-5-CARBOXAMIDE;2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide;N-(2-chloro-6-methylphenyl)-2-amino-5-thiazolecarboxamide;2-aminothiazole-5-carboxylic acid (2-chloro-6-methylphenyl)amide;
分子式:C11H10ClN3OS
分子量:267.735
精确质量:267.023
Psa:96.25
Logp:3.5936
中文别名:2-氨基-N-(2-氯-6-甲基苯基)-5-噻唑酰胺;
英文别名:2-amino-N-(2-cliloro-6-metliylplienyl)thiazole-5-carboxamide;2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide;2-AMINO-N-(2-CHLORO-6-METHYLPHENYL)THIAZOLE-5-CARBOXAMIDE;2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide;N-(2-chloro-6-methylphenyl)-2-amino-5-thiazolecarboxamide;2-aminothiazole-5-carboxylic acid (2-chloro-6-methylphenyl)amide;
分子式:C11H10ClN3OS
分子量:267.735
精确质量:267.023
Psa:96.25
Logp:3.5936
编号系统
EINECS号:608-455-2
物化性质
密度:1.474 g/cm3
沸点:362ºC at 760 mmHg
闪点:172.7ºC
折射率:1.714
沸点:362ºC at 760 mmHg
闪点:172.7ºC
折射率:1.714
安全信息
海关编码:2934100090
生产方法及用途
用途
达沙替尼的中间体。
达沙替尼的中间体。
合成路线
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参考文献
WO2008/76883 A2, ; Page/Page column 53-54 ; WO 2008/076883 A2
上游原料
下游产品
图谱
13C NMR : Predict
1H NMR : Predict








