Chlormadinone acetate (INN, USAN, BAN, JAN) (sold under brand names including Clordion, Gestafortin, Lormin, Non-Ovlon, Normenon, Verton, and many others), sometimes abbreviated as CMA, and also known as 17α-acetoxy-6-chloro-6-dehydroprogesterone, is a steroidal progestin with additional antiandrogen and antigonadotropic (and by extension antiestrogenic) effects. CMA has been used in the treatment of vaginal bleeding, oligomenorrhea, polymenorrhea, hypermenorrhea, secondary amenorrhea, and endometriosis. It has also been used clinically as a hormonal contraceptive, and in part due to its capacity to lower estrogen levels, but also for improved effectiveness in contraception, chlormadinone has frequently been combined with ethinyl estradiol for this purpose.

CAS：302-22-7
中文别名：氯化孕酮-17乙酸酯;17α-Acetoxy-6-chloro-4,6-pregnadiene-3,20-dione;氯地孕酮醋酸盐;17-乙酰基-6-氯-6-脱氧孕酮;
英文别名：6-chloro-17-hydroxypregna-4,6-diene-3,20-dione acetate;Retex;rs1280;Lormin;Natrol;chlormadinone;Verton;ST 155;CMA;Cero;MATROL;6-Chloro-17α-hydroxy-4,6-pregnadiene-3,20-dione 17-acetate,Gestafortin,Matrol;6-Chloro-6-dehydro-17α-acetoxyprogesterone;
分子式：C23H29ClO4
分子量：404.927
精确质量：404.175
Psa：60.44
Logp：4.7517

UNII：0SY050L61N

外观与性状：结晶固体
密度：1.23g/cm3
沸点：512.5ºC at 760mmHg
熔点：212ºC
闪点：172.5ºC
折射率：1.562

安全说明：53-22-36/37/39-45
危险类别码：R60; R61; R40; R48
危险品标志：T

生产方法
由17α-羟基黄体酮为原料经一系列反应得到。 与雌激素配合制成长效口服避孕药。
用途
与雌激素配合制成长效口服避孕药。