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  • 8-甲氧基补骨脂素

    methoxsalen

化合物简介

Methoxsalen — also called xanthotoxin, marketed under the trade names Oxsoralen, Deltasoralen, Meladinine — is a drug used to treat psoriasis, eczema, vitiligo, and some cutaneous lymphomas in conjunction with exposing the skin to UVA light from lamps or sunlight. Methoxsalen modifies the way skin cells receive the UVA radiation, allegedly clearing up the disease. The dosage comes in 10mg tablets, which are taken in the amount of 30mg 75minutes before a PUVA (psoralen + UVA) light treatment. Chemically, methoxsalen belongs to a class of organic natural molecules known as furanocoumarins. They consist of coumarin annulated with furan. It can also be injected and used topically.

基本信息

CAS:298-81-7
中文别名:花椒毒素;甲氧沙林;甲氧基补骨脂素;
英文别名:9-methoxypsoralen;Puvalen;Xanthotoxin;8-methoxypsoralene;8-MP;8-MOP,9-Methoxyfuro[3,2-g][1]benzopyran-7-one,Ammoidin;Methoxsalen;Puvamet;Dermox;xanthotoxin;Meloxine;7H-Furo[3,2-g][1]benzopyran-7-one, 9-methoxy-;9-Methoxy-7H-furo[3,2-g]chromen-7-one;Uvadex;8-MOP,8-Methoxypsoralen,9-Methoxyfuro[3,2-g][1]benzopyran-7-one;8-MOP;Vitpso;Metoxin;8-Methoxypsoralen;Ammodin;
分子式:C12H8O4
分子量:216.19
精确质量:216.042
Psa:52.58
Logp:2.5478

编号系统

MDL号:MFCD00005009

物化性质

外观与性状:无气味的白色至奶油色的结晶固体,苦味道
密度:1.368g/cm3
沸点:414.8ºC at 760mmHg
熔点:148-150°C(lit.)
闪点:204.7ºC
折射率:1.635
水溶解性:PRACTICALLY INSOLUBLE
稳定性:Stable under normal temperatures and pressures. May decompose when exposed to light.
储存条件:Corrosives area. Keep containers tightly closed. Store protected from light. Store in a cool, dry area away from incompatible substances.
蒸汽压:4.33E-07mmHg at 25°C

安全信息

RTECS号:LV1400000
安全说明:S36/37-S53-S45-S36/37/39-S26
WGK Germany:3
危险类别码:R22; R34; R45; R46
海关编码:2932999099
危险品运输编码:3216
危险类别:6.1
包装等级:I; II; III
危险品标志:T

生产方法及用途

用途
用于治疗牛皮癣、白癫风等疾病

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图谱

Predict 1H proton NMR


13C NMR : Predict


1H NMR : Predict


1H NMR : 90 MHz in CDCl3


Mass spectrum (electron ionization)


Mass


Raman : 4880 A,200 M,powder


IR : KBr disc


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