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21-羟基-5Alpha-孕甾(烷)-3,20-二酮
(5S,8R,9S,10S,13S,14S,17S)-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
化合物简介
5α-Dihydrodeoxycorticosterone (abbreviated as DHDOC), also known as 21-hydroxy-5α-pregnan-20-one, is an endogenous progestogen and neurosteroid. It is synthesized from the adrenal hormone deoxycorticosterone (DOC) by the enzyme 5α-reductase type I. DHDOC is an agonist of the progesterone receptor, as well as a positive allosteric modulator of the GABAA receptor, and is known to have anticonvulsant effects.
基本信息
CAS：298-36-2
中文别名：
英文别名：5alpha-Pregnan-21-ol-3,20-dione;5alpha-Dihydro-11-deoxycorticosterone;Pregnane-3,20-dione,21-hydroxy-,(5alpha);Allopregnane-21-ol-3,20-dione;21-Hydroxy-5alpha-pregnane-3,20-dione;5alpha-Dihydrodeoxycorticosterone;5alpha-Pregnane-3,20-dione,21-hydroxy;
分子式：C21H32O3
分子量：332.477
精确质量：332.235
Psa：54.37
Logp：3.7758
中文别名：
英文别名：5alpha-Pregnan-21-ol-3,20-dione;5alpha-Dihydro-11-deoxycorticosterone;Pregnane-3,20-dione,21-hydroxy-,(5alpha);Allopregnane-21-ol-3,20-dione;21-Hydroxy-5alpha-pregnane-3,20-dione;5alpha-Dihydrodeoxycorticosterone;5alpha-Pregnane-3,20-dione,21-hydroxy;
分子式：C21H32O3
分子量：332.477
精确质量：332.235
Psa：54.37
Logp：3.7758
编号系统
物化性质
密度：1.11g/cm3
沸点：468.6ºC at 760mmHg
闪点：251.3ºC
折射率：1.531
蒸汽压：9.42E-11mmHg at 25°C
沸点：468.6ºC at 760mmHg
闪点：251.3ºC
折射率：1.531
蒸汽压：9.42E-11mmHg at 25°C
安全信息
WGK Germany：3
生产方法及用途
生产方法
可用21-羟基孕甾-4-烯-3,20-二酮-21-醋酸酯经水解脱除乙酰基,然后催化氢化制得该品。 羟孕酮琥酯钠的中间体。
用途
羟孕酮琥酯钠的中间体。
可用21-羟基孕甾-4-烯-3,20-二酮-21-醋酸酯经水解脱除乙酰基,然后催化氢化制得该品。 羟孕酮琥酯钠的中间体。
用途
羟孕酮琥酯钠的中间体。
合成路线
上游原料
下游产品
图谱
13C NMR : Predict
1H NMR : Predict
