Guanfacine (brand name Estulic, Tenex and the extended release Intuniv) is a sympatholytic drug used in the treatment of attention deficit hyperactivity disorder (ADHD) and hypertension (not to be confused with guaifenesin, an expectorant). It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone.

CAS：29110-47-2
中文别名：氯酰胍;N-脒基-2-(2,6-二氯苯基)乙酰胺;
英文别名：Guanfacina;Lon798;[(2,6-Dichlorophenyl)acetyl]guanidine;Estulic;Guanfacina [INN-Spanish];Guanfacine [INN:BAN];Tenex;GUANFACINE;N-(aminoiminomethyl)-2,6-dichlorobenzeneacetamide;N-amidino-2-(2,6-dichlorophenyl)acetamide;Intuniv;Guanfacinum;Guanfacinum [INN-Latin];
分子式：C9H9Cl2N3O
分子量：246.093
精确质量：245.012
Psa：78.97
Logp：2.7365

EINECS号：249-442-8

沸点：424.9ºC at 760 mmHg
闪点：210.8ºC
蒸汽压：2E-07mmHg at 25°C

海关编码：2925290090