α-Hydroxyglutaric acid (2-hydroxyglutaric acid) is an alpha hydroxy acid. In humans the compound is formed by a hydroxyacid-oxoacid transhydrogenase whereas in bacteria is formed by a 2-hydroxyglutarate synthase. The compound can be converted to α-ketoglutaric acid through the action of a 2-hydroxyglutarate dehydrogenase which, in humans, are two enzymes called D2HGDH and L2HGDH. Deficiency in either of these two enzymes lead to a disease known as 2-hydroxyglutaric aciduria.

CAS：2889-31-8
中文别名：
英文别名：Pentanedioic acid, 2-hydroxy-;2-hydroxyglutarate;
分子式：C5H6O5--
分子量：146.098
精确质量：146.022
Psa：100.49
Logp：-3.3727