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  • beta-(氨基甲基)-4-甲基-苯丙酸盐酸盐

    4-amino-3-(4-methylphenyl)butanoic acid

化合物简介

Tolibut, also known as 3-(p-tolyl)-4-aminobutyric acid (or β-(4-methylphenyl)-GABA), is drug that was developed in Russia. It is an analogue of γ-aminobutyric acid (GABA) (that is, a GABA analogue) and the 4-methyl analogue of phenibut, and is also an analogue of baclofen where the 4-chloro substitution has been replaced with a 4-methyl substition. Tolibut has been described as possessing analgesic, tranquilizing, and neuroprotective properties. It is not fully clear as to whether the drug was ever approved or used medically in Russia, though it may have been. Tolibut probably acts as a GABAB receptor agonist similarly to phenibut and baclofen.

基本信息

CAS:28311-38-8
中文别名
英文别名:4-amino-3-(p-tolyl)butanoic acid;Tolibut;3-p-Tolyl-4-amino-buttersaeure (rac.);
分子式:C11H15NO2
分子量:193.242
精确质量:193.11
Psa:63.32
Logp:2.2123

编号系统

物化性质

沸点:345.5ºC at 760mmHg
闪点:162.7ºC

安全信息

海关编码:2922499990

生产方法及用途

合成路线

  • 参考文献

    Biswas, Kallolmay; Gholap, Rajesh; Srinivas, Padakanti; Kanyal, Sachin; Sarma, Koushik Das RSC Advances, 2014 , vol. 4, # 5 p. 2538 - 2545

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图谱

1H NMR : Predict


13C NMR : Predict


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