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化合物简介

Flupentixol (INN), also known as flupenthixol (former BAN), marketed under brand names such as Depixol and Fluanxol is a typical antipsychotic drug of the thioxanthene class. It was introduced in 1965 by Lundbeck. In addition to single drug preparations, it is also available as flupentixol/melitracen—a combination product containing both melitracen (a tricyclic antidepressant) and flupentixol. Flupentixol is not approved for use in the United States. It is, however, approved for use in the UK, Australia, Canada, Russian Federation, South Africa, New Zealand, Philippines and various other countries.

基本信息

CAS:2709-56-0
中文别名:4-(3-(2-(三氟甲基)-9H-噻吨-9-亚基)丙基)-1-哌嗪乙醇;
英文别名:n7009;[3H]-(Z)-Flupentixol;siplaril;fluanxol;fluxanxol;Flupentiol;emergil;siplarol;lc44;flupentixol;
分子式:C23H25F3N2OS
分子量:434.518
精确质量:434.164
Psa:52.01
Logp:4.4775

编号系统

UNII:21HMQ851IS

物化性质

外观与性状:白色或灰白色固体
密度:1.306g/cm3
沸点:554.7ºC at 760mmHg
闪点:289.3ºC
折射率:1.607

安全信息

RTECS号:TL9900000
安全说明:36/37/39
WGK Germany:3
危险类别码:R20/21/22
危险品运输编码:UN 2811 6.1/PG 3
危险品标志:Xn

生产方法及用途

合成路线

  • 参考文献

    LABORATORIO CHIMICO INTERNAZIONALE S.P.A. Patent: WO2005/37820 A1, 2005 ; Location in patent: Page/Page column 8-9 ;

上游原料

下游产品

图谱

13C NMR : Predict


1H NMR : Predict


Mass spectrum (electron ionization)


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